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SUMMARY:What do hereditary cancer genes actually do? | Journal Club with Pete Shaw & Bob Kaplan
DESCRIPTION:This month we will dive deeper into hereditary cancer genes. \nLast month we explored Bob Kaplan’s new paper on the nature of hereditary cancer syndromes. His paper makes a case for the metabolic theory of cancer as it relates to the precise mutations many cite as proof for the somatic mutation theory. \nBut have you ever wondered what functions they perform under normal conditions or even during exercise? \nJoin us to find out. \nFeatured papers: \n\nKaplan et al (2025): Hereditary cancer syndromes linked to oxidative phosphorylation insufficiency\nNemkov et al (2023): Metabolic Signatures of Performance in Elite World Tour Professional Male Cyclists\nTarpey et al (2021): Skeletal Muscle Function Is Dependent Upon BRCA1 to Maintain Genomic Stability\nPark et al (2009): p53 improves aerobic exercise capacity and augments skeletal muscle mitochondrial DNA content\n\nBecome a member of The Medical Society today for access to this discussion and our entire archive of past sessions.
URL:https://brokenscience.org/event/what-do-hereditary-cancer-genes-actually-do-journal-club-with-pete-shaw-bob-kaplan/
LOCATION:Online
CATEGORIES:Journal Clubs,Medical,MetFix
ATTACH;FMTTYPE=image/png:https://brokenscience.org/wp-content/uploads/2026/02/JournalClub-11-HereditaryCancer-1.png
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