Cancer as a metabolic disease: implications for novel therapeutics

Mounting evidence is showing that cancer is indeed a metabolic disease, and not the result of genetic mutations. Given this cause, Thomas Seyfried et. al., explain methods for treating cancer, including diet, drugs effecting energy metabolism, and hyperbaric oxygen therapy.

December 2013 article first published in Carcinogenesis

“The metabolic shift from glucose metabolism to ketone body metabolism creates an anti-angiogenic, anti-inflammatory and pro-apoptotic environment within the tumor mass. The general concept of a survival advantage of tumor cells over normal cells occurs when fermentable fuels are abundant, but not when they are limited.”