The
Daily
Fix
4 rounds for time:
Ground Chicken Crust Pizza with Garlic Butter & Mozzarella
Skeletal Muscle Function Is Dependent Upon BRCA1 to Maintain Genomic Stability
100-m farmer carry
10 kettlebell snatches
10 kettlebell snatches, other arm
400-m run
A savory, golden-crusted pizza made from seasoned ground chicken, topped with rich tomato, melted cheese, and finished with a drizzle of olive oil and fresh herbs.
The BRCA1 gene may play a key role in maintaining mitochondrial function and energy metabolism in skeletal muscle.
Carry two kettlebells, then snatch one.
Men use 24-kg KBs.
Women use 16-kg KBs.
Post time to comments.
Ingredients
For the Chicken Crust:
16 oz. ground chicken (preferably thigh meat for better fat content)
1 large egg
2 oz. grated Parmesan cheese
½ tsp garlic powder
½ tsp onion powder
½ tsp dried oregano
½ tsp salt
¼ tsp black pepper
1 Tbsp melted butter or tallow (for brushing before baking)
For the Toppings:
4 oz. mozzarella cheese, shredded
2 oz. full-fat ricotta or mascarpone (optional for creaminess)
3 Tbsp sugar-free tomato purée or crushed tomatoes
½ tsp dried basil
½ tsp oregano
1 small clove garlic, minced
1 Tbsp butter (for sautéing garlic)
6–8 slices pepperoni or cooked bacon (optional)
Salt and pepper, to taste
1 tsp olive oil (for finishing)
Macronutrients
(per serving, ¼ pizza)
Protein: 40g
Fat: 35g
Carbs: 4g
Preparation
Preheat the oven to 200°C (400°F) and line a baking tray with parchment paper.
In a bowl, combine ground chicken, egg, Parmesan, garlic powder, onion powder, oregano, salt, and pepper. Mix until well combined.
Spread the mixture onto the parchment in a thin, even circle about 10–12 inches wide. Press firmly to ensure it’s compact.
Brush the top lightly with melted butter or tallow.
Bake for 15–18 minutes until lightly golden and firm. Remove from the oven and carefully blot off any excess moisture with a paper towel.
While the crust bakes, melt 1 Tbsp butter in a small pan over low heat. Add garlic and sauté for 1 minute.
Stir in tomato purée, basil, oregano, salt, and pepper. Simmer for 2–3 minutes, then remove from heat.
Spread the tomato sauce evenly over the cooked chicken crust.
Top with mozzarella, dollops of ricotta (if using), and optional pepperoni or bacon.
Bake again for 8–10 minutes, until the cheese is melted and bubbling.
Drizzle lightly with olive oil and garnish with fresh herbs or cracked pepper.
Slice and enjoy warm — rich, crisp, and full of flavor.
In this review, Michael D. Tarpey and colleagues examine the role of the BRCA1 protein in skeletal muscle and propose that it helps maintain muscle function by protecting genomic stability in both the nucleus and mitochondria. While BRCA1 is widely known as a tumor-suppressor gene linked to breast cancer risk, the authors present evidence that it is also expressed in skeletal muscle and localizes to mitochondria, where it appears to support normal energy metabolism. Experiments deleting BRCA1 in mouse skeletal muscle led to impaired mitochondrial respiration, abnormal mitochondrial structure, increased DNA damage, and reduced muscle force production. These findings suggest that BRCA1 may help preserve mitochondrial function and cellular energy balance, with genetic instability emerging as a downstream consequence of metabolic disruption. From this perspective, the research adds to a growing body of evidence that many diseases—including cancer—may be better understood through the lens of mitochondrial and metabolic dysfunction rather than genetics alone.
WEDNESDAY 260401