Research Manipulation Part V: Looking Even Closer
Breaking down composite endpoints to their component parts.
Breaking down composite endpoints to their component parts.
In this video Emily explains the difference between a Bayesian approach and a frequentist approach to analyzing statistics. A Bayesian analysis looks at prior probabilities combined with data to determine the probability that the hypothesis is true. A frequentist analysis compares the hypothesis to the null-hypothesis, a yes/no approach, to determine if the data could support the null-hypothesis. It then ranks the data with a P-value, but it actually says nothing about the hypothesis being true.
Harvard medical school ‘research-integrity officer’ was co-author of studies in question.
Explaining how a clinical trial can report success – when there is none.
In February of 2023 Dr. Kendrick spoke at BSI’s event in Phoenix, AZ. Malcom’s presentation recaps the history of the diet-heart hypothesis, the supposed link between cholesterol and cardiovascular death, and how drug companies have fooled doctors into prescribing medications that are harming patients rather than helping them.
Scientific misconduct is ever becoming more recognized as a problem, yet what exactly constitutes misconduct varies by source.
Simply put, a p-value is a measure of the likelihood that the results of a study are due to the hypothesis, and not simply a result of chance. It compares the “null hypothesis,” the idea that the thing being studied has no effect, vs the “alternative hypothesis,” the thing being tested. So if the p-value is low, the data is thought to be significant. However, the p-value does not validate the effectiveness of the thing being studied, it simply claims to shows that the results were not due to chance.
Frighteningly, scientists, researchers, and medical professionals misinterpret the meaning of p-values but place extreme faith in them.
In this edition Malcolm explains how study results can be carefully worded, to imply results that are actually contrary to data.
On his podcast, Emily and Dr. Drew talked at length about the overuse of statins to treat coronary heart disease.
Faults with a Stanford study’s claims that a vegan diet is better for cardio metabolic health.
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