In the frantic information world we now live in, few of us can be bothered to pay close attention to…well, pretty much anything. Yes, we have our own areas of interest. We know a great deal about certain things and will happily spend time and effort finding out more. As for almost everything else ‘Give me a headline, it’s all I need. Life is too short.’ So, many important things pass most people by. Or, as Winston Churchill once remarked. ‘A lie gets halfway around the world before the truth has a chance to get its boots on.’ Here is a headline for you, from 2017.

“Amgen Announces Repatha® (Evolocumab) Significantly Reduced The Risk Of Cardiovascular Events In FOURIER Outcomes Study.’

(I highlighted the word ‘events’) Just to fill in a little background here. Repatha is the brand name of the drug evolocumab. It is an injectable LDL/cholesterol lowering agent. It lowers the LDL level to a far greater degree than statins. Therefore, in theory at least, it should reduce the risk of dying of cardiovascular disease to a far greater degree than statins. Repatha was the first in a new class of LDL lowering agents, known as PCSK-9 inhibitors. There are now several of them. They only cost several hundred times as much as statins. Bargain. To return to the headline. What it states – or appears to state – is that Repatha significantly reduces the risk of cardiovascular ‘events.’ If you read the whole paper, it expands on that statement. Explaining that there was a:

“15% reduction in the risk of the primary composite end point of cardiovascular death, myocardial infarction, stroke, hospitalization for unstable angina, or coronary revascularization.”

And a

“20% reduction in the risk of the more clinically serious key secondary end point of cardiovascular death, myocardial infarction, or stroke.”

These reinforce the finding that Repatha showed significant benefits on cardiovascular health… over and above anything that statins can provide. [Everyone on this trial also had to take a statin as this represents ‘standard’ treatment and could not ‘ethically’ be withheld]. Now, dear reader, I would like you to stop for a moment and take in a deep breath. Spend a few moments thinking about what you believe these headline statements mean. I am unable to read your thoughts, but I am guessing you probably believe that Repatha reduces the risk of dying of a myocardial infarction (heart attack), and stroke, by twenty per cent – over and above statins. How else are we supposed to interpret the statement: A “20% reduction in the risk of the more clinically serious key secondary end point of cardiovascular death, myocardial infarction, or stroke.” Which does sound pretty damned good. At this point, I would like to make it clear that this statement is correct. I am not questioning the facts it presents – although I do have my doubts about the validity of the underlying research. Doubts that can wait for another day. However, despite being unable to read your mind, I can pretty much guarantee that both statements don’t mean what you think they mean. Whatever you currently think they mean. Unfortunately, digging beneath the headlines does take some time. I hope you find it time well spent. What is a cardiovascular event? The issue to start with here is the following. What is a cardiovascular (CV) ‘event.’ A CV event can be many different things. It can be a heart attack. It can be a stroke. It can be an episode of angina. It can be a fatal heart attack, or a fatal stroke. Or atrial fibrillation, or Takotsubo cardiomyopathy, or a heart arrhythmia. Or a rise in cardiac enzymes. It could be having a stent put in. The full list would be very long indeed. In short, the term ‘CV event’ is broad enough to range from something you were unaware happened at the time, to something that kills you. Even if you try to narrow things down to look at a specific CV event, these come in many different shapes and sizes too. A myocardial infarction, for instance. A man, or woman, clutches at their chest in agony, falls to the floor, then dies. This certainly happens. I would call this a ‘bad’ myocardial infarction a.k.a. heart attack. As bad as it gets. How about a man, or woman, who has a stent put in? A stent is a small latticework metal tube inserted in coronary arteries to open it up and improve blood flow, this technique has pretty much replaced coronary artery bypass graft surgery. What most people do not know is that this procedure often results in heart muscle/myocardial damage. This is confirmed by the release of an enzyme called troponin. An enzyme that normally sits within myocardial cells, but if myocardial cells die, troponin is released into the bloodstream, where it can be measured with a blood test. In almost 70 percent of cases, stent insertion can result in a troponin level considered high enough, in other situations, to diagnose a heart attack. From the paper ‘Peri-Procedural Troponin Elevation after Percutaneous Coronary Intervention for Left Main Coronary Artery Disease.’

“Despite the great efficiency and high safety, it should be emphasized that LM PCI* are challenging and highly invasive procedure. Periprocedural myocardial injury (Troponin (Tn) > 99th percentile) is frequently discovered after LM PCI, being recognized even up to 67% of patients using a standard Tn assay.”

*left main coronary artery percutaneous coronary intervention (a stent). Did the patient know that they had, technically, suffered a heart attack during stent insertion? Were they even told? Should they have been? Discuss. Leaving that issue behind, the main point I want to emphasize here is that cardiovascular ‘events’ come in many different shapes and sizes. And even something that sounds like it could be a single thing, e.g. a heart attack, can present in many different ways. From deadly, to something only discovered by a blood test. All of which means that, when a clinical trial press release uses the word ‘events’, an urgent little alarm sounds within my brain. Awakening me to the fact that critically important information is quite deliberately being hidden from you, me, and everybody else. “Come Watson! The game is Afoot!”