The
Daily
Fix
Rest
Blackened Salmon with Creamy Avocado Cucumber Salad
Why Most Published Research Findings Are False
Rest day
Bold, smoky blackened salmon served with a cool, creamy cucumber and avocado salad.
On the reliability of scientific claims
Enjoy the recovery time, or make-up anything you missed from last week.
Ingredients
For the Salmon:
6 oz wild-caught salmon fillet
1 Tbsp butter (for searing)
1 tsp smoked paprika
½ tsp garlic powder
½ tsp onion powder
½ tsp dried thyme
¼ tsp cayenne pepper (adjust to taste)
¼ tsp sea salt
¼ tsp black pepper
1 Tbsp olive oil (for finishing)
For the Creamy Avocado Cucumber Salad:
½ small avocado, diced
½ cup cucumber, diced
2 Tbsp full-fat sour cream
1 Tbsp olive oil
1 Tbsp lemon juice
1 Tbsp fresh dill, chopped (or parsley)
¼ tsp sea salt
¼ tsp black pepper
Macronutrients
Protein: 44g
Fat: 550g
Carbs: 9g
Preparation
Prepare the Blackened Salmon: In a small bowl, mix smoked paprika (1 tsp), garlic powder (½ tsp), onion powder (½ tsp), dried thyme (½ tsp), cayenne pepper (¼ tsp), sea salt (¼ tsp), and black pepper (¼ tsp). Pat the salmon fillet (6 oz) dry with paper towels. Rub the seasoning mix evenly over both sides of the salmon. Melt the butter (1 Tbsp) in a skillet over medium-high heat. Sear the salmon skin-side down for 3–4 minutes until crispy. Flip and cook another 2–3 minutes, or until the salmon reaches your preferred doneness. Remove from heat and drizzle lightly with olive oil (1 Tbsp).
Prepare the Creamy Avocado Cucumber Salad: In a bowl, combine the diced avocado (½ small), diced cucumber (½ cup), full-fat sour cream (2 Tbsp), olive oil (1 Tbsp), lemon juice (1 Tbsp), chopped fresh dill (1 Tbsp), sea salt (¼ tsp), and black pepper (¼ tsp). Gently mix to combine, keeping the avocado slightly chunky. Chill until ready to serve.
Assemble the Dish: Plate the creamy avocado cucumber salad. Top with the blackened salmon fillet. Serve immediately with an extra drizzle of olive oil if desired.
In this essay, John Ioannidis argues that most published research findings are likely false due to small study sizes, low statistical power, flexible study designs, selective reporting, and conflicts of interest. He shows mathematically that as research fields test more hypotheses with weak effects, the probability that any given “significant” finding is true decreases sharply. The essay highlights how bias, repeated testing, and the pressure to publish positive results distort the scientific record. Ultimately, Ioannidis calls for larger, better-powered studies, stricter standards, and a shift away from overreliance on p-values to improve the credibility of research.
SATURDAY 250920