The
Daily
Fix
Rest
Cod Coconut Curry with Fresh Herbs & Lime Drizzle
Fructose and glucose from sugary drinks enhance colorectal cancer metastasis via SORD
Rest day
Tender cod simmered in a rich, spiced coconut cream sauce, seared in butter and finished with cold-pressed olive oil and fresh lime.
Combined sugars fuel tumor spread through altered redox and metabolic pathways
Enjoy the recovery time, or make-up anything you missed from last week.
Ingredients
For the Cod & Curry:
6 oz cod fillet (fresh or thawed)
1 Tbsp butter or tallow (for searing)
¼ tsp sea salt
¼ tsp black pepper
1 Tbsp butter (for sauce)
½ tsp ground turmeric
½ tsp curry powder
½ tsp ground ginger
1 clove garlic, minced
¼ tsp chili flakes (optional, for heat)
½ cup full-fat coconut milk (canned, unsweetened)
1 Tbsp fresh lime juice
1 Tbsp chopped fresh cilantro or parsley
Optional Side:
½ cup steamed cauliflower rice (unsalted)
1 tsp butter (to finish)
Pinch of salt and turmeric (for color)
Finishing:
1 tsp extra virgin olive oil (drizzled cold at the end)
Fresh lime wedge
Macronutrients
(w/o cauli rice)
Protein: 38g
Fat: 42g
Carbohydrates: 5g
Preparation
Sear the Cod: Pat cod dry and season both sides with sea salt (¼ tsp) and black pepper (¼ tsp). Heat butter or tallow (1 Tbsp) in a skillet over medium-high heat. Sear cod for 2–3 minutes per side, until golden and opaque in the center. Remove and set aside.
Make the Coconut Curry Sauce: In the same skillet, lower heat to medium. Add butter (1 Tbsp), minced garlic (1 clove), turmeric (½ tsp), curry powder (½ tsp), ground ginger (½ tsp), and chili flakes (¼ tsp). Stir the spices for 30 seconds to bloom. Pour in coconut milk (½ cup) and stir well to combine. Simmer gently for 3–4 minutes until slightly thickened.
Stir in lime juice (1 Tbsp) and fresh herbs (1 Tbsp).
Combine & Finish: Return the seared cod to the pan. Spoon sauce over the top and let simmer gently for 1–2 minutes to reheat. Plate with optional buttered cauliflower rice. Drizzle 1 tsp olive oil over the top just before serving, and garnish with extra herbs and lime.
This Nature Metabolism study uncovers how sugar-sweetened beverages (SSBs)—containing both glucose and fructose—can accelerate colorectal cancer (CRC) metastasis. In cell and mouse models, the glucose–fructose mix (mimicking soda or high-fructose corn syrup) increased cancer cell motility and liver metastases compared to glucose alone. Mechanistically, the combination activated the enzyme sorbitol dehydrogenase (SORD) in reverse, raising the NAD⁺/NADH ratio and fueling glycolysis and the mevalonate pathway—key drivers of cancer cell migration. Human tumor data confirmed high SORD expression in metastatic CRC. The findings provide a biological explanation for epidemiological links between sugary drink intake and worse CRC outcomes, suggesting that targeting SORD or limiting SSBs may help curb metastasis.
Hopefully more studies like this can help the masses see this picture more clearly.