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Red Wine and Bone Broth Braised Short Ribs

Individual variations in glycemic responses to carbohydrates and underlying metabolic physiology

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Photo of Red Wine and Bone Broth Braised Short Ribs

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Beef short ribs slow-braised in red wine, bone broth, and aromatics for a rich meal.

Continuous glucose monitoring reveals metabolic subtypes linked to food-specific blood sugar spikes

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Ingredients

1½ lbs beef short ribs (bone-in)
Salt and pepper, to taste
1 Tbsp butter or ghee (for searing)
¼ cup red onion, chopped
2 cloves garlic, minced
1 cup dry red wine (no added sugar)
1½ cups beef bone broth (homemade or no additive store-bought)
1 sprig fresh rosemary
2 sprigs fresh thyme
½ tsp smoked paprika
1 Tbsp apple cider vinegar (optional, for balance)
1 Tbsp fresh parsley, chopped
Drizzle of olive oil (finishing only)

Macronutrients

Protein: 145g
Fat: 145g
Carbs: 8g

Preparation

Pat ribs dry and season all sides generously with salt and pepper. In a Dutch oven or deep oven-safe pot, melt butter or ghee over medium-high heat. Sear the ribs 2–3 minutes per side until browned. Remove and set aside.

In the same pot, reduce heat to medium and add onions. Cook for 3–4 minutes until softened. Add garlic and smoked paprika and cook for another 30 seconds.

Pour in red wine to deglaze the pan, scraping up the browned bits. Simmer for 5 minutes to reduce slightly. Add bone broth, apple cider vinegar (if using), rosemary, and thyme. Return the ribs to the pot, making sure they’re mostly submerged in liquid.

Cover tightly and transfer to a 300°F (150°C) oven. Braise for 2½ to 3 hours, or until the meat is fork-tender and falling off the bone.

Remove ribs and herbs from the pot. Simmer braising liquid on the stovetop if needed to thicken slightly. Plate ribs with a ladle of reduced sauce, fresh parsley, and a finishing drizzle of olive oil.

A Stanford-led Nature Medicine study used continuous glucose monitoring in 55 participants to uncover striking individual differences in post-meal blood sugar responses (PPGRs) to seven standardized carbohydrate foods. Although rice caused the highest average glucose spikes, each person’s strongest response varied — some were “potato-spikers,” “bread-spikers,” or “grape-spikers.” Those who spiked most to potatoes tended to be insulin resistant with poorer beta-cell function, while grape-spikers were insulin sensitive. Preloading rice meals with fat, protein, or fiber reduced spikes modestly overall, but only in insulin-sensitive individuals. Multi-omics profiling linked these glycemic patterns to specific lipids, metabolites, and gut microbiome signatures. The study shows that individualized blood sugar responses reflect underlying metabolic physiology, suggesting that personalized dietary guidance may better prevent type 2 diabetes and cardiovascular disease than fixed glycemic index measures.

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COMMENTS

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Ricardom77 October 20, 2025 | 08:55 EST
30:08s
92.5 kgs bw and on the bar
Mile done in 11:48 an 10:58
Ethan Rush October 20, 2025 | 19:58 EST
Edited
Scaled - 14:20
Half mile treadmill runs and 185# squat machine (hotel gym constraints)
Pat McElhone October 21, 2025 | 10:13 EST
Scaled to 2x35lbs DB PC
21:00
CoachSroka8 October 21, 2025 | 14:12 EST
25.10
80kg
jillray October 21, 2025 | 15:19 EST
Scaled 25:50
Bike
BW 133
Barbell 115#
Paulina Braden October 18, 2025 | 19:01 EST
I was interested by the finding that individuals classified as “rice-spikers” were enriched among Asian participants, and those identified as “potato-spikers” had worse insulin resistance and beta cell function. This makes me think about nutrition epidemiology and if/how much of it plays a role in what we are more prone to being sensitive to.
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