In this blog post, Tim Ferriss recounts how a strict ketogenic diet helped him overcome severe Lyme disease after conventional antibiotic treatment left lingering and debilitating symptoms. After contracting Lyme twice, with one case leaving him functionally impaired for months, Ferriss adopted a very low-carbohydrate ketogenic diet (under ~20 g/day). Within about a week his cognitive symptoms resolved, and after roughly 4–6 weeks of strict ketosis he reports being completely asymptomatic for more than a decade. He has since seen similar results in four friends. Ferriss frames ketosis as a potentially simple, low-risk approach worth trying for 1–2 months during or after antibiotic treatment. The post also explores mechanisms that may explain his experience—such as the Lyme bacterium’s reliance on glucose metabolism and ketosis’s effects on mitochondrial function, inflammation, and alternative brain fuel.

https://tim.blog/2026/01/30/lyme-disease-ketogenic-diet/