Published last month, this paper brings together clinicians experienced with ketogenic metabolic therapy to outline practical guidance for using it in adults with major depressive disorder, bipolar disorder, and schizophrenia. The authors note that growing evidence links serious mental illness to metabolic dysfunction, including insulin resistance, inflammation, and impaired brain energy metabolism, which has increased interest in ketogenic therapy as a potential adjunctive treatment. Drawing on clinical experience and a structured expert review process, the group developed 33 recommended statements covering how ketogenic therapy should be defined, which patients may be appropriate candidates, and how treatment should be implemented and monitored. The recommendations emphasize that ketogenic therapy should typically be used alongside standard psychiatric care, with attention to safety considerations such as medication adjustments, electrolyte balance, hydration, and laboratory monitoring.

https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2026.1749406/full