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261012

MONDAY 261012
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20-minute AMRAP:

Steak and Arugula Squash Salad

CAR-T & GBM: More hope in the war on cancer

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Complete as many rounds as possible in 20 minutes of:

100-ft walking lunge
15 push presses
500-m row

Flank steak served over a bed of peppery arugula with sweet caramelized onions, roasted butternut squash, and a tangy balsamic dressing.

And more evidence that victory isn’t defined by survival or quality of life

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The
Daily
Fix

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Use the same load for the push presses that you used for the thrusters last Thursday.

Post load used and number of rounds completed to comments.

Ingredients

4 ½ oz flank steak
¼ red onion, thinly sliced
2 tsp butter (for cooking)
2 Tbsp olive oil
1 Tbsp balsamic vinegar
2 cups arugula
¼ cup butternut squash, cubed
Salt and pepper to taste

Nutrition Facts:

Protein: 35g
Fat: 40g
Carbs: 8g

Preparation

Heat a pan over medium heat and add butter (2 tsp). Once melted, add red onion (¼ onion, thinly sliced) and butternut squash (¼ cup, cubed). Cook for 8-10 minutes, stirring occasionally, until the onions are soft and caramelized and the squash is tender. Remove from heat and set aside.

Season flank steak (5 oz) with salt and ground black pepper (to taste).

Heat a grill or pan over medium-high heat. Cook the steak for 3-4 minutes per side for medium-rare, or longer if you prefer a more well-done steak.

Remove the steak from the heat and let it rest for 5 minutes before slicing.

While the steak rests, prepare the dressing by whisking together balsamic vinegar (1 Tbsp), dijon mustard (½ tsp) and olive oil (2 Tbsp) in a small bowl.

Once the steak is rested, thinly slice the steak diagonally against the grain for tenderness.

To assemble the salad, place arugula (2 cups) on a plate. Add the caramelized onions and butternut squash on top.  Arrange the sliced steak over the salad, then drizzle with the dressing and top with blue cheese crumbles.  Serve immediately.

Early CAR-T trials for glioblastoma are showing tumor shrinkage, sometimes within days. But this article argues that better scans are not the same thing as better outcomes.

Across three small phase I studies, some patients had significant tumor responses, but most responses were temporary. In the largest study, involving 65 patients with recurrent high-grade glioma, median overall survival was about eight months—within the range previously reported for recurrent GBM—and there was no control group to establish that CAR-T extended survival. The treatment also caused significant neurological and other toxicities in some patients.

The takeaway: CAR-T may be a promising direction for GBM, but the real test is whether it helps patients **live longer and better**, not simply whether it makes tumors look smaller on an MRI.

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COMMENTS

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Kyle Lynch October 12, 2026 | 17:59 EST
20-minute AMRAP:
100-ft walking lunge
15 push presses 15lb DBs
24 Cal Bike
TR: 5 Rounds
troybruun October 12, 2026 | 18:00 EST
6rds
100’ Walking Lunge
15 DB Push Press (20lbs)
M Row(as many meters as possible while Emily finishes the lunge and press) avg 350m
Ethan Rush October 12, 2026 | 23:07 EST
DB Push Press (25# DBs)
3 rounds + 100ft + 15 Reps
BSage October 13, 2026 | 12:45 EST
3rnds +10 lunges
35# barbell push press
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