This clip from the MetFix Foundations Seminar uses a nightclub analogy to explain how diet drives insulin resistance and chronic disease. In the analogy, insulin is a promoter, encouraging nutrients into the club (the cell), while Ross the bouncer (ROS) regulates entry. Normally, the system works, but excess refined carbs and seed oils trick the bouncer into letting in too much, overcrowding the cell. This leads to leakage (free fatty acids spilling into the bloodstream), rigid cell walls, and eventually systemic insulin resistance.

The resulting hyperinsulinemia—the body pumping out more insulin to compensate—sets off a vicious cycle of fat storage, reduced fat burning, and accumulation of triglycerides. Excess fat then gets stored in and around organs (ectopic and visceral fat), causing fatty liver, fatty pancreas, and widespread inflammation. These changes impair organ function and further worsen insulin resistance.

Key markers like hemoglobin A1C reveal the damage through glycation, where sugar binds to proteins and accelerates aging and disease. The progression from insulin resistance to hyperinsulinemia to organ damage underlies obesity, diabetes, cardiovascular disease, and more.

The takeaway: processed carbs and seed oils disrupt cellular balance. Avoiding these foods, supporting mitochondrial health, and monitoring blood sugar can help prevent insulin resistance and its cascade of chronic conditions.

The course took place August 23–24, 2025, in Southborough, MA.