The mitochondrial-stem cell connection (MSCC) theory builds on the metabolic theory of cancer, which holds that cancer originates primarily from impaired energy metabolism in cells—specifically dysfunctional oxidative phosphorylation (OxPhos) in the mitochondria—rather than solely from genetic mutations. In the MSCC model, when stem cells lose efficient mitochondrial function, they can transform into cancer stem cells (CSCs), which drive tumor growth, recurrence, and resistance to treatment. Conventional therapies often target DNA mutations but do not restore mitochondrial function or eradicate CSCs, which can limit long-term success.

To address this gap, Baghli and colleagues propose a hybrid orthomolecular protocol that combines seven therapeutic strategies, including high-dose vitamins, repurposed drugs, dietary interventions, and lifestyle measures. The approach is designed to enhance OxPhos, restrict glucose and glutamine metabolism (the primary fuels for cancer cells), and directly target CSCs and metastasis. By correcting underlying mitochondrial dysfunction and disrupting cancer’s metabolic pathways, this integrated method aims to address root causes rather than just symptoms, offering a potentially more durable and comprehensive treatment strategy.

https://isom.ca/article/targeting-the-mitochondrial-stem-cell-connection-in-cancer-treatment-a-hybrid-orthomolecular-protocol/