This paper is frequently referenced by us at BSI, as it aligns perfectly with our belief that the primary cause of chronic diseases lies in energy metabolism.

In it, Thomas Seyfried and colleagues argue that cancer should be understood primarily as a metabolic disease, rooted in disturbances of cellular energy metabolism—specifically, compromised mitochondrial respiration paired with a shift toward fermentation for energy production. They propose that genomic instability and other hallmark traits of cancer are downstream consequences of underlying mitochondrial dysfunction, rather than initiating causes. As a result, they suggest that therapeutic strategies targeting this metabolic foundation—such as promoting the use of ketone bodies over glucose and glutamine, paired with metabolic therapies—may offer more effective and less toxic cancer treatments.