In this study, Eric D. Queathem and colleagues examined how ketone production affects the progression of fatty liver disease. They found that as liver disease worsens, the liver increases ketone production and fat oxidation, suggesting the body may be trying to protect itself from excess fat buildup. When researchers disabled the liver’s ability to produce ketones in mice, fat accumulated more easily and liver damage increased. However, other experiments showed that the protective effects of ketone production cannot be explained by fat burning alone. The findings suggest that ketone production may help stabilize liver metabolism in several ways, highlighting the role of mitochondrial energy pathways in metabolic liver disease.

https://pmc.ncbi.nlm.nih.gov/articles/PMC12165805/