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Cheesy Spinach and Artichoke Stuffed Peppers

How Mitochondria Control Your Metabolism

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Photo of Cheesy Spinach and Artichoke Stuffed Peppers

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Stuffed peppers filled with cheesy spinach, artichokes, and seasoned beef

Dr. Jared Rutter on how cells allocate energy

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Ingredients

2 medium bell peppers, halved and seeded
½ lb ground beef
½ Tbsp butter or beef tallow (for cooking)
1 cup fresh spinach, chopped
½ cup artichoke hearts, chopped (preferably marinated, drained)
2 oz cream cheese, softened
¼ cup shredded mozzarella cheese
1 small onion, finely chopped
1 clove garlic, minced
¼ tsp coarse sea salt
¼ tsp cracked black pepper
½ tsp dried Italian herbs (optional)
½  Tbsp extra virgin olive oil (for finishing)
Fresh parsley or basil, chopped (for garnish)

Macronutrients

Protein: 65g
Fat: 70g
Carbs: 25g

Preparation

Preheat oven to 375°F (190°C). In a large skillet, melt butter or tallow (½  Tbsp) over medium heat. Add onion (1 small) and garlic (1 cloves) and sauté until fragrant and translucent, about 3–4 minutes.

Add ground beef (½  lb), salt (¼ tsp), pepper (¼ tsp), and dried Italian herbs (½  tsp, optional). Cook until beef is browned and cooked through, breaking it up as you go.

Stir in chopped spinach (1 cup) and artichoke hearts (½ cup), cooking until spinach wilts, about 2–3 minutes.

Remove from heat and stir in cream cheese (2 oz) and half of the shredded mozzarella (⅛ cup) until well combined.

Spoon the beef and cheese mixture into halved bell peppers (4 halves), filling each generously.

Place stuffed peppers in a baking dish and sprinkle remaining mozzarella cheese (⅛ cup) on top.

Bake uncovered for 20–25 minutes until peppers are tender and cheese is melted and bubbly.

Remove from oven and drizzle extra virgin olive oil (½ Tbsp total, divided) over the stuffed peppers.

Garnish with chopped fresh parsley or basil.

Andrew Huberman talks with biochemist Jared Rutter about mitochondria as far more than the cell’s “powerhouse.” Rutter explains that metabolism is really the combined activity of trillions of individual cells, each deciding how to use available nutrients. Mitochondria sit at the center of those decisions, helping determine whether fuel is burned to make ATP or directed toward building and maintaining cells. When that resource allocation changes, it can contribute to aging, heart disease, cancer, and other disorders.

They also discuss Rutter’s discovery of the mitochondrial pyruvate carrier, lactate as both fuel and metabolic signal, and how excess energy in mitochondria may increase reactive oxygen species and cellular damage. Cancer provides a particularly interesting example: Rutter describes the Warburg effect and how cancer cells redirect metabolism away from maximizing ATP production and toward producing the material needed to make more cells.

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BSage September 08, 2026 | 17:36 EST
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Ethan Rush September 08, 2026 | 18:03 EST
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