In this webinar for the Broken Science Initiative Medical Society, veterinarian and researcher Peter Doberilski discusses his exploration into metabolism, focusing on the “protons hypothesis” and the roles of reactive oxygen species (ROS), protons, and electrons in energy production. Prompted by personal health struggles and early academic exposure, Peter’s curiosity led him to delve deeper into the biochemical differences between glucose and fatty acid metabolism. Through his blog,”Hyperlipid,” he developed and shared a nuanced understanding of how the electron transport chain, influenced by the NADH/FADH2 ratio, affects ROS generation—key players in cellular signaling and energy regulation. His work rethinks the conventional interpretation of ROS and insulin resistance, emphasizing their roles as adaptive, not merely pathological, responses.
Peter also touches on how different dietary fats impact metabolic health. He highlights that insulin resistance can serve as a protective mechanism rather than a purely negative condition, particularly in energy surplus states. Saturated fats may induce insulin resistance but provide a stable energy source, while polyunsaturated fats like linoleic acid enhance insulin sensitivity but may promote fat storage and obesity. His analysis of uncoupling agents and adipocyte function underscores the complexity of fat metabolism.
Peter’s research offers a compelling framework for better understanding obesity and insulin-related disorders.
This BSI Medical Society Webinar was streamed on May 19th, 2025.
A 10-minute summary of the webinar is available here free, for anyone, while the full webinar is available for Medical Society Members in their dashboard.
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At the 2026 Unbreakable Health Retreat in Miami, Emily Kaplan hosted a panel with Bob Kaplan, Professor Thomas Seyfried, and Dr. Derek Lee on what it means to treat cancer as a metabolic disease. They discussed the glucose-ketone index (GKI), nutritional ketosis, and strategies aimed at restricting the fuels cancer cells depend on while considering how metabolic therapy can fit alongside standard cancer treatment.
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An abbreviated version of this discussion is available here, for free.
At the 2026 Unbreakable Health Retreat in Miami, Professor Thomas Seyfried presented the case that cancer is fundamentally a mitochondrial metabolic disease rather than primarily a genetic one. He contrasts the dominant somatic mutation theory with a metabolic model in which impaired mitochondrial respiration drives a shift toward fermentation, dysregulated cell growth, and the mutations commonly associated with cancer.
Citing the work of Otto Warburg and research from his lab at Boston College, Seyfried explains how cancer cells rely heavily on fermentable fuels—particularly glucose and glutamine—and why mitochondrial dysfunction sits upstream of many of the genetic abnormalities seen in tumors. He also discusses reactive oxygen species, altered cellular signaling, and the role of mitochondria in regulating cell growth and behavior.
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An abbreviated version of this discussion is available here, for free.
MetFix and BSI Members can view the full 54-minute video.
Would it be possible to share audio-only versions of these webinar summaries, as well as recent talks, on the Broken Science podcast? This would make it easier to listen to content offline and/or while on the go with device screen turned off :) Thanks!