Category: Video
Category: Video
Metabolic health, medical education, and the case for bringing clinicians and coaches together
Inside Dave Feldman’s KetoCa study and the questions surrounding its data, analysis, and quality control
Paradigm Shifts, Entrenched Thinking, and the Future of Medicine
Mark Sisson separates longevity fads from the habits that consistently improve health and performance
At the 2026 Unbreakable Health Retreat in Miami, Emily Kaplan hosted a panel with Bob Kaplan, Professor Thomas Seyfried, and Dr. Derek Lee on what it means to treat cancer as a metabolic disease. They discussed the glucose-ketone index (GKI), nutritional ketosis, and strategies aimed at restricting the fuels cancer cells depend on while considering how metabolic therapy can fit alongside standard cancer treatment.
The conversation also addressed the practical realities patients face when trying to pursue a metabolic approach within the conventional oncology system, including questions about nutrition, repurposed drugs, inherited cancer risk, and how to evaluate different treatment options. Seyfried and Lee connected these clinical questions back to mitochondrial dysfunction, fermentation, and the metabolic vulnerabilities that may offer additional targets for cancer treatment.
An abbreviated version of this discussion is available here, for free.
At the 2026 Unbreakable Health Retreat in Miami, Professor Thomas Seyfried presented the case that cancer is fundamentally a mitochondrial metabolic disease rather than primarily a genetic one. He contrasts the dominant somatic mutation theory with a metabolic model in which impaired mitochondrial respiration drives a shift toward fermentation, dysregulated cell growth, and the mutations commonly associated with cancer.
Citing the work of Otto Warburg and research from his lab at Boston College, Seyfried explains how cancer cells rely heavily on fermentable fuels—particularly glucose and glutamine—and why mitochondrial dysfunction sits upstream of many of the genetic abnormalities seen in tumors. He also discusses reactive oxygen species, altered cellular signaling, and the role of mitochondria in regulating cell growth and behavior.
The presentation then turns to the therapeutic implications of this model. Seyfried explains strategies aimed at placing tumor cells under metabolic stress by restricting the fuels they depend on, including ketogenic metabolic therapy and approaches targeting glucose and glutamine. For Seyfried, the therapeutic target follows directly from the biology: restrict the fuels cancer cells depend on, exploit their metabolic weaknesses, and treat mitochondrial dysfunction as the central feature of the disease.
An abbreviated version of this discussion is available here, for free.
MetFix and BSI Members can view the full 54-minute video.
At the 2026 Unbreakable Health Retreat in Miami, Dr. Drew Pinsky hosted Dr. Jila Senemar, Emily Kaplan, and Dr. Jaime Seeman for a wide-ranging discussion on women’s health, hormones, and longevity. The panel begins with the fallout from the Women’s Health Initiative and the widespread retreat from hormone replacement therapy, exploring how interpretations of risk reshaped clinical practice and continue to influence women today.
From there, the conversation expands into menopause, testosterone, cardiovascular and bone health, sexual health, metabolic dysfunction, PCOS, breast screening, and the importance of maintaining muscle and strength with age. The panel emphasizes the need to look beyond isolated symptoms and evaluate women as whole patients, weighing risk and benefit rather than relying on rigid, one-size-fits-all recommendations. The discussion ultimately makes the case for a more individualized and scientifically literate approach to women’s health—one that gives women better information, more options, and greater agency over their long-term health.
An abbreviated version of this discussion is available here, for free.
