At the 2026 Unbreakable Health Retreat in Miami, OB/GYN Dr. Jaime Seeman presents how conventional medicine can miss the larger picture of women’s health by focusing on isolated markers while overlooking hormones, skeletal muscle, insulin resistance, and body composition. She begins with the story of her own mother, who followed medical advice for decades yet entered her 70s with severe cardiovascular disease, prediabetes, osteoporosis, and significant muscle loss.
Seeman explains how the loss of estrogen during menopause can affect metabolism, cardiovascular health, brain function, bone density, and mitochondrial function, and why hormonal health must be considered alongside nutrition, exercise, sleep, and other lifestyle factors. She then turns to skeletal muscle, describing its critical roles in glucose regulation, metabolic health, resilience during illness, and healthy aging—and argues that resistance training remains one of the most powerful tools for preserving strength and function over time.
The larger message is that weight, BMI, cholesterol, and other familiar measurements tell only part of the story. By paying greater attention to muscle, visceral fat, hormones, and metabolic health, Seeman makes the case for a more complete approach to preventing disease and extending healthspan.
An abbreviated version of this discussion is available here, for free.
MetFix and BSI Members can view the full video here (members only).
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Metabolic health, medical education, and the case for bringing clinicians and coaches together
At the 2026 Unbreakable Health Retreat in Miami, Emily Kaplan hosted a panel with Bob Kaplan, Professor Thomas Seyfried, and Dr. Derek Lee on what it means to treat cancer as a metabolic disease. They discussed the glucose-ketone index (GKI), nutritional ketosis, and strategies aimed at restricting the fuels cancer cells depend on while considering how metabolic therapy can fit alongside standard cancer treatment.
The conversation also addressed the practical realities patients face when trying to pursue a metabolic approach within the conventional oncology system, including questions about nutrition, repurposed drugs, inherited cancer risk, and how to evaluate different treatment options. Seyfried and Lee connected these clinical questions back to mitochondrial dysfunction, fermentation, and the metabolic vulnerabilities that may offer additional targets for cancer treatment.
An abbreviated version of this discussion is available here, for free.
At the 2026 Unbreakable Health Retreat in Miami, Professor Thomas Seyfried presented the case that cancer is fundamentally a mitochondrial metabolic disease rather than primarily a genetic one. He contrasts the dominant somatic mutation theory with a metabolic model in which impaired mitochondrial respiration drives a shift toward fermentation, dysregulated cell growth, and the mutations commonly associated with cancer.
Citing the work of Otto Warburg and research from his lab at Boston College, Seyfried explains how cancer cells rely heavily on fermentable fuels—particularly glucose and glutamine—and why mitochondrial dysfunction sits upstream of many of the genetic abnormalities seen in tumors. He also discusses reactive oxygen species, altered cellular signaling, and the role of mitochondria in regulating cell growth and behavior.
The presentation then turns to the therapeutic implications of this model. Seyfried explains strategies aimed at placing tumor cells under metabolic stress by restricting the fuels they depend on, including ketogenic metabolic therapy and approaches targeting glucose and glutamine. For Seyfried, the therapeutic target follows directly from the biology: restrict the fuels cancer cells depend on, exploit their metabolic weaknesses, and treat mitochondrial dysfunction as the central feature of the disease.
An abbreviated version of this discussion is available here, for free.
MetFix and BSI Members can view the full 54-minute video.
